{"created":"2023-06-19T11:40:56.991972+00:00","id":1202,"links":{},"metadata":{"_buckets":{"deposit":"78d43fef-266f-4941-88c1-8b9dad2efd5a"},"_deposit":{"created_by":14,"id":"1202","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"1202"},"status":"published"},"_oai":{"id":"oai:setsunan.repo.nii.ac.jp:00001202","sets":["196:197"]},"author_link":["2072","2071"],"item_10007_contributor_5":{"attribute_name":"研究分担者","attribute_value_mlt":[{"contributorNames":[{"contributorName":"山口, 政光"}],"nameIdentifiers":[{},{}]}]},"item_10007_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"摂南大学","subitem_description_type":"Other"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"転写因子Nuclear Factor Y Box (NF‐Y)は真核生物間で広く保存されており、三つのサブユニットNF‐YA,NF‐YB,NF‐YCの三量体で機能する転写因子である。ショウジョウバエNF-YA(dNF-YA)と脂質分解酵素lipase4(lip4)は遺伝学的に相互作用していることが示唆されており、ルシフェラーゼアッセイ、クロマチン免疫沈降法の結果によりNF‐YがLip4遺伝子の発現制御を行うことが示唆された。一方、脂肪体特異的にNF‐YAをノックダウンすると蓄積されている油滴の縮小が見られた。これらの結果はNF-Yが遺伝子制御によって脂質代謝に関与する事を示唆している。 ","subitem_description_type":"Abstract"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"15K07162","subitem_description_type":"Other"}]},"item_10007_link_24":{"attribute_name":"リンク","attribute_value_mlt":[{"subitem_link_url":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K07162/15K07162seika/"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脂肪体","subitem_subject_scheme":"Other"},{"subitem_subject":"NF-Y","subitem_subject_scheme":"Other"},{"subitem_subject":"脂質代謝","subitem_subject_scheme":"Other"},{"subitem_subject":"ショウジョウバエ","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipase遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"転写","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉岡, 泰秀"}],"nameIdentifiers":[{},{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"転写因子NF-Yが制御する脂質代謝機構の解析と新規肝機能モデルの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"転写因子NF-Yが制御する脂質代謝機構の解析と新規肝機能モデルの開発"}]},"item_type_id":"10007","owner":"14","path":["197"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-04"},"publish_date":"2019-07-04","publish_status":"0","recid":"1202","relation_version_is_last":true,"title":["転写因子NF-Yが制御する脂質代謝機構の解析と新規肝機能モデルの開発"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-06-19T11:56:36.021404+00:00"}