{"created":"2023-06-19T11:40:57.267036+00:00","id":1206,"links":{},"metadata":{"_buckets":{"deposit":"a518db2d-682e-4289-8212-d495aceea4f0"},"_deposit":{"created_by":14,"id":"1206","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"1206"},"status":"published"},"_oai":{"id":"oai:setsunan.repo.nii.ac.jp:00001206","sets":["196:197"]},"author_link":["2083","2082"],"item_10007_contributor_5":{"attribute_name":"研究分担者","attribute_value_mlt":[{"contributorNames":[{"contributorName":"荒木, 良太"}],"nameIdentifiers":[{},{}]}]},"item_10007_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"摂南大学","subitem_description_type":"Other"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BDNF遺伝子のプロモーター領域におけるメチル化が精神疾患の発症に関与する可能性が示されている。本研究では、BDNF遺伝子のプロモーター領域とルシフェラーゼ遺伝子をNeuro2A細胞のゲノムに挿入することで、プロモーター領域のメチル化状態を簡便に評価できるアッセイ系を構築した。本アッセイ系は、BDNF遺伝子のプロモーター領域を脱メチル化できる創薬シーズを探索する際に有用である可能性が考えられる。 ","subitem_description_type":"Abstract"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"15K08011","subitem_description_type":"Other"}]},"item_10007_link_24":{"attribute_name":"リンク","attribute_value_mlt":[{"subitem_link_url":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K08011/15K08011seika/"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"DNAメチル化","subitem_subject_scheme":"Other"},{"subitem_subject":"生理活性物質","subitem_subject_scheme":"Other"},{"subitem_subject":"天然物化学","subitem_subject_scheme":"Other"},{"subitem_subject":"エピジェネティクス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"稲冨, 由香"}],"nameIdentifiers":[{},{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"DNAメチル化制御機構を標的にした新規精神疾患治療薬の創薬シーズの探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DNAメチル化制御機構を標的にした新規精神疾患治療薬の創薬シーズの探索"}]},"item_type_id":"10007","owner":"14","path":["197"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-04"},"publish_date":"2019-07-04","publish_status":"0","recid":"1206","relation_version_is_last":true,"title":["DNAメチル化制御機構を標的にした新規精神疾患治療薬の創薬シーズの探索"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-06-19T11:56:32.311522+00:00"}