{"created":"2023-06-19T11:40:57.337618+00:00","id":1207,"links":{},"metadata":{"_buckets":{"deposit":"ed1d0489-953c-4675-bdbe-099867997d8f"},"_deposit":{"created_by":14,"id":"1207","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"1207"},"status":"published"},"_oai":{"id":"oai:setsunan.repo.nii.ac.jp:00001207","sets":["196:197"]},"author_link":["2084"],"item_10007_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"摂南大学","subitem_description_type":"Other"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ダカルバジン（DTIC）は悪性黒色腫や褐色細胞腫の治療薬として広く用いられている抗がん剤である．しかし，光により分単位でDiazo-ICに分解され，血管痛を引き起こすため，血管痛を軽減できるDTICの投与方法の構築には臨床からの強い要請がある．本申請課題では，１）Diazo-ICへの分解を抑制できる調製方法を確立し，２）動物モデルを用いて疼痛を軽減できる前投薬医薬品を明らかとした．さらに，３）DTICの調製から投与開始までの時間を短縮することで血管痛の発症を抑制できることを明らかとした． \n ","subitem_description_type":"Abstract"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"15K08117","subitem_description_type":"Other"}]},"item_10007_link_24":{"attribute_name":"リンク","attribute_value_mlt":[{"subitem_link_url":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K08117/15K08117seika/"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ダカルバジン","subitem_subject_scheme":"Other"},{"subitem_subject":"Diazo-IC","subitem_subject_scheme":"Other"},{"subitem_subject":"血管痛","subitem_subject_scheme":"Other"},{"subitem_subject":"ザルトプロフェン","subitem_subject_scheme":"Other"},{"subitem_subject":"臨床薬学","subitem_subject_scheme":"Other"},{"subitem_subject":"薬剤誘発生血管炎","subitem_subject_scheme":"Other"},{"subitem_subject":"薬剤誘発性血管炎","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河野, 武幸"}],"nameIdentifiers":[{},{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ダカルバジンの安全な投与レジメンの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ダカルバジンの安全な投与レジメンの開発"}]},"item_type_id":"10007","owner":"14","path":["197"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-04"},"publish_date":"2019-07-04","publish_status":"0","recid":"1207","relation_version_is_last":true,"title":["ダカルバジンの安全な投与レジメンの開発"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-06-19T11:56:31.543342+00:00"}